JAKA Biotech gave a global debut to Gavient PY, its neuro-soothing skin care active ingredient, at this month’s PCHi trade show in Hangzhou, China.
Gavient PY targets the excessive activation of TRPV1/TRPV4 channels in keratinocytes, thus reducing glutamate overproduction at the source.
Meanwhile, it inhibits glutamate receptor activation in neuron-like cells to block abnormal signal transmission of nerve impulses.
During the development process, innovative biological models of cell-to-cell communication and ‘glutamatergic neurotransmission functionality’ were constructed for the first time.
In vitro tests show that Gavient PY can significantly inhibit the abnormal activation of TRPV4, TRPV1, PAR2, and HRH1 receptors at extremely low doses.
In neuron-like cell model, Gavient PY can effectively suppress the activation of glutamate receptor activation, simultaneously down-regulate glutamate release, and block abnormal signal transmission of nerve impulses.
In clinical tests, both lactic acid stinging and capsaicin stimulation models show that Gavient PY at a dosage of 0.1% can rapidly relieve skin discomforts caused by external stimuli within five minutes.
Long-term use can significantly enhance the skin's tolerance to external irritants.
Shanghai-based JAKA Biotech also showcased Lumiroot GD, its newly launched whitening ingredient.
Its core component is glabridin, a classic and widely recognized whitening ingredient. Compared to ordinary glabridin, Lumiroot GD innovatively targets the process of melanin transport, acting on the PAR2 receptor in keratinocyte membrane.
Once activated, the PAR2 receptor, which serves as a switch for melanin transmission, essentially allows melanin to pass through, causing keratinocytes to engulf a large number of these melanosomes.
Therefore, the mechanism of action of Lumiroot GD involves reducing the uptake of melanosomes by keratinocytes by inhibiting the activation of PAR2.
With fewer melanosomes in keratinocytes, the skin will not appear dull.
Clinical tests have shown that Lumiroot GD can rapidly reduce the skin's melanin index (MI value) and increase the skin's ITA° value within seven days, significantly improving skin brightness within 14 days.
Furthermore, Lumiroot GD has also achieved breakthroughs in the extraction process. Glabridin itself has low solubility, but through encapsulation technique, the water solubility of Lumiroot GD has been significantly enhanced.
