Samyang KCI describes a charge-induced interaction- based retinol stabilization nanocarrier technology that addresses instability, low absorption, and skin irritation.
Retinol (vitamin A1, all-trans-retinol) has been one of the most iconic and extensively studied active ingredients in the field of anti-ageing skin care since the 1940s. It plays a vital role in regulating cell growth and differentiation, boosting collagen synthesis in the dermis, and supporting skin renewal and exfoliation, which delivers visible improvements in wrinkles, firmness, pigmentation, and overall texture.
Despite its remarkable efficacy, retinol comes with a major challenge: instability. When exposed to light, heat, oxygen, moisture, or metal ions, the molecule easily oxidizes and degrades, leading to a rapid loss of activity.
This not only reduces its effectiveness in formulations but can also generate oxidative by-products that irritate the skin. As a result, retinol has earned the widespread reputation of being powerful, yet highly sensitive.
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