Bridging the in vivo and in vitro testing gap

As mineral sunscreens become more widely adopted, ensuring accurate SPF testing methodologies becomes increasingly urgent. Refining in vitro SPF testing will allow for a more accurate and fair assessment of ZnO-based sunscreen efficacy, as Solabia explains

Mineral sunscreens, particularly those formulated with zinc oxide (ZnO), are well recognized for their broad-spectrum ultraviolet (UV) protection and favorable safety profile. Among UV filter ingredients, ZnO and titanium dioxide (TiO2) are the only two recognized as generally safe and effective (GRASE) by the U.S. Food and Drug Administration (FDA). In addition to UV protection, they provide benefits such as anti-inflammatory and antimicrobial properties, making them particularly suitable for sensitive or acne-prone skin.

Mineral sunscreens, particularly those formulated with zinc oxide (ZnO), are well recognized for their broad-spectrum ultraviolet (UV) protection and favorable safety profile. Among UV filter ingredients, ZnO and titanium dioxide (TiO2) are the only two recognized as generally safe and effective (GRASE) by the U.S. Food and Drug Administration (FDA). In addition to UV protection, they provide benefits such as anti-inflammatory and antimicrobial properties, making them particularly suitable for sensitive or acne-prone skin.

With growing consumer demand for natural, sensitive skin—friendly sun care products and regulatory restrictions on certain organic UV filters in some markets, formulations containing only ZnO or a combination of TiO2 and ZnO are becoming increasingly prevalent. Compared to TiO2-based sunscreens, ZnO formulations provide more comprehensive UV coverage and better transparency across diverse skin tones.

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